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Advanced Gastric or GEJ Adenocarcinoma

Watch leading oncologists discuss treatment beyond first-line therapy

WATCH VIDEO

Metastatic non-small cell lung cancer

Review challenging clinical mNSCLC cases from esteemed colleagues

Dr. Camidge presents a challenging case of aggressive mNSCLC

VIEW CASE

Metastatic colorectal cancer

Review the RAISE trial design, a phase III study of CYRAMZA in combination with FOLFIRI vs FOLFIRI alone.

REVIEW TRIAL

RESOURCES

Watch your colleagues share their candid insights on treatment and patient care.

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CLINICAL CASE: DAVID ROSSCAMIDGE, MD, P h D

An esteemed colleague presents a challenging case of an mNSCLC patient with rapidly progressing disease

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ITT Population

Rapid Progression Subgroup

Statistically significant delay in disease progression in the ITT population

Half of patients who received CYRAMZA in combination with docetaxel achieved an estimated 4.5 months or longer PFS vs 3.0 months or longer for docetaxel alone

SUPPORTIVE OUTCOME MEASURE

CI=confidence interval; PFS=progression-free survival.

The phase III REVEL trial evaluated the efficacy and safety of CYRAMZA plus docetaxel vs placebo plus docetaxel in patients with metastatic NSCLC with disease progression on or after platinum-based chemotherapy. Major efficacy outcome measure was overall survival. Supportive efficacy outcome measures were progression-free survival and objective response rate. All patients were required to have Eastern Cooperative Oncology Group performance status 0 or 1. Patients were randomized 1:1 to receive either CYRAMZA 10 mg/kg (n=628) or placebo (n=625), in combination with docetaxel at 75 mg/m 2 every 21 days. 1

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